Monolithic microfabricated valves and pumps by multilayer soft lithography. We routinely work with customers to solve the design and manufacturing challenges that other manufacturers cant or wont even attempt. ; writingoriginal draft preparation, X.Z. For both the air blower system and the mouth blowing system without the valve, the flow variations were far higher than in the valve incorporated systems, just as the figures clearly reveal. Receive updates on this section every two weeks. Both the sinusoidal wave pressures and the square wave pressures fluctuated from 6 kPa to 12 kPa within a time period of 10 s, and the flow rates were recorded at every 0.01 s. The pressure range was determined for the constant flow phase under the static experiments. ; validation, A.E.O. The ellipsoidal surface design of the control chamber leaves quite an accommodating enclosure for the membrane to deflect into, thus facilitating a flow resistance development that could increase significantly, even under the low pressures. Two micro-holes, each with a diameter of 200 m were designed in the membrane with a Centre Distance of 1000 m between them. Although the flow variations under the time-dependent pressures were much higher than in the static test, the valve still showed a great capability of regulating the flow. Passive flow-rate regulators using pressure-dependent autonomous deflection of parallel membrane valves. Yi Y., Zaher A., Yassine O., Kosel J., Foulds I.G. 
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We obtained a mean flow rate of 4.03 0.17 mL/min (flow variation ~4.22%) in the above pressure range.
In addition, for the sake of cost-effectiveness and portability, the microvalve should be wholly actuated on-chip with energy efficiency. Figure 7b shows the flow rates of the gas-driven flow system driven by the air blower. As a manufacturer with over a century of experience, we have built our company to not only create the Metal and Plastic valve solutions that solve a huge range of flow control challenges, but also to manufacture and assemble them in the numbers and time-scales you need to support your production operations. Bethesda, MD 20894, Web Policies 4054 Brewster Way Because we specialize in ball check valves and similar items, we usually have something suitable for your requirements in stock, even for out-of-the-ordinary projects. ; writingreview and editing, X.Z. As the two membranes could restrict liquid in the fluidic channel with the autonomous deflection, the valve was capable of achieving flow regulation at a minimum pressure of 15 kPa. We also designed some orientation pillars and holes in each part for ease and accuracy of assembly. Oh K.W., Ahn C.H. Pourmand A., Shaegh S.A.M., Ghavifekr H.B., Najafi Aghdam E., Dokmeci M.R., Khademhosseini A., Zhang Y.S. and A.E.O. {{#pushedProductsPlacement4.length}}
In the square wave pressure experiment, we found out that flow rate abruptly increased and decreased to give peak flow and valley points when the pressures were on high and low pulsations, respectively. Automated microfluidic instrument for label-free and high-throughput cell separation. {{#each pushedProductsPlacement4}}, {{#pushedProductsPlacement5.length}} A planar compliance-based self-adaptive microfluid variable resistor. Kartalov et al. In addition, the valve structure can be further optimized to reduce the flow rate for more available microfluidic applications, such as sample mixing [41], droplet manipulation [42], drug delivery [43], etc. The system was found to output a stable liquid under the low driving pressures, which validated the applicability of the valve in portable microfluidics. (b) Simulated flow rate versus the inlet pressure in the valve. An integrated electrostatic peristaltic 18-stage gas micropump with active microvalves.
The microvalve was demonstrated to successfully regulate the steady flow delivery in the system under the low driving pressures produced by the above gas sources. Recent trends in mechanical micropumps and their applications: A review. In this work, we developed a new microfluidic passive valve which can produce a constant flow rate of liquid under an ultra-low threshold pressure.
The new PMC design is here! In the experiment, the inlet liquid pressure of the valve was increased sequentially from 1 kPa to 17 kPa by 1 kPa step. The overall force for controlling liquid in the microvalve should be minimized for convenient actuation. The flow variation defined as the relative pulsation to the mean flow rate was calculated as a ratio of the bilateral tolerance of minimum to maximum flow to the overall mean flow rate. The Riverside, CA 92501 USA -, {{product.productPrice.formattedPriceMax}}, THE LEE COMPANY miniature solenoid valves. Hence, as the valve was able to maintain a constant flow under such a low threshold pressure, we can envision its usefulness in many microfluidic applications. The explosion view shows the four parts of the valve, and the cross-section view shows the inner structure of the valve. An electrostatic microvalve for pneumatic control of microfluidic systems. When you cant find a catalog item to fill your applications requirements, we offer full custom manufacturing services to ensure you have the exact valve solution for your unique needs. Careers. The conceptualized system was composed of a pressure source, a sealed tank filled with deionized water and a microfluidic valve, shown in Figure 7a. We thought the behavior of the flow pulsation was directly influential to the response of the self-adaptive resistance variation of the valve. The air pressure produced by a strong mouth blowing was about 6.1 kPa to 8.2 kPa, which was a little higher than the minimum threshold pressure of the valve for flow stabilization. Used in applications where back flow is not permitted, or must be redirected. The pressure source employed was that of a human mouth whose blown air pressure was considered enough to drive the liquid. sharing sensitive information, make sure youre on a federal Our team had previously reported a parallel membrane valve with two horizontal membranes sandwiching a fluidic channel between them, and then all sandwiched between two control channels [34,35]. We are committed to providing every customer with a timely, consistent service that enables you to plan production, confident that the inline check valve or compressor check valve parts needed will arrive in line with the agreed schedule. Co. offers a broad range of custom brass check valve, pneumatic check valve and one way check valve options, as well as numerous other valves and related components. An experimental study on the numbering-up of microchannels for liquid mixing. Furthermore, as the design in such of an inline configuration, liquid flows directly into the control chamber from the inlet, leaving no room for pressure loss in the valve, unlike in many traditional valves made up of exterior control channels. Unger M.A., Chou H.-P., Thorsen T., Scherer A., Quake S.R. Unstable pressure Pf was produced by an air blower and by human mouth to drive liquid in the system, and stable flow rate Qs was achieved in the system. National Library of Medicine CJ20190054). Cousseau P., Hirschi R., Frehner B., Gamper S., Maillefer D. Technical Digest. Guevara-Pantoja P.E., Jimenez-Valdes R.J., Garcia-Cordero J.L., Caballero-Robledo G.A. However, these existing passive valves can be difficult to integrate into useful microfluidic due to their high threshold pressures for flow regulation. The site is secure. (d) Photograph showing the prototype functional parts of the valve. 1College of Mechanical and Electrical Engineering, Hohai University, Changzhou 213022, China; nc.ude.uhh@imeyeso.ea, 2School of Mechanical Engineering, and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing 211189, China. In the simulation, a significant nonlinear relationship was observed between the flow rate and the inlet pressure, which is attributable to the self-adaptive resistance variation characteristic of the valve as illustrated in Figure 2b. It is necessary to investigate whether the valve is indeed capable of regulating flow rate through self-adaptive resistance variation when the inlet liquid pressure varies with the actuation time. ; methodology, X.Z. To further examine the flow stability of the valve, we employed it in a portable gas-driven flow system which was operated by an air blower and human mouth blowing, respectively. (a) Simulated velocity magnitude in the valve. As described in the figure, the response time for the flow rate stabilization under the pulsating pressures was less than 0.3 s, and the standard deviation of the stable flow rate was 0.36 mL/min with the flow variation of 9.04%. Zhang X., Zhang Z. Microfluidic passive flow regulatory device with an integrated check valve for enhanced flow control. (f) Image showing the micro-holes in the membrane at position A in Figure 4d.
After that, the slope of the Q(P) curve became very small and went down to zero gradually. (e) Photograph showing a prototype of the assembled valve.
The system without the valve driven by mouth blowing showed some dramatic flow fluctuations, with a mean flow rate of 10.44 2.05 mL/min (19.64% variation). The seal layer and the membrane were designed in AutoCAD software (AutoCAD 2013, Autodesk Inc., San Rafael, CA, USA) and transferred to a UV laser machine (AWAVE 355-10W-30K, Advanced Optowave Corporation, Suffolk, NY, USA) for cutting and engraving. The black and blue dash lines represent the sinusoidal pressure and the square pressure, while the green and red solid lines represent the flow rates of the valve under the above two pressures, respectively. Flow rates of the microfluidic passive valve under varied inlet pressures. An active valve with pneumatic actuation usually employs off-chip apparatus such as an air-compressor, a pressure regulator, etc., and does the required flow regulation by the regulation of the air pressure. The inlet pressures were varied in sinusoidal wave mode and square wave mode, respectively. The standard deviation of the flow rate under sinusoidal wave pressures was 0.31 mL/min, which was equivalent to a flow variation of 7.75%. Generally, the geometry of the microvalve should be designed for a potential large-scale integration. 8600 Rockville Pike and A.E.O. Our customers frequently operate based on tight time constraints and need a resource they can rely on for the parts they need. As the commercial syringe pumps or peristaltic pumps are bulky in size while expensive in cost, it is necessary to develop a cost-effective small sized pump. (a) Concept structure of the valve. In the first phase, the flow rate was in direct proportionality to the inlet pressure, and it increased steadily as the pressure increased from 1 kPa to 6 kPa. The UV laser technology used to cut out the micro-holes in the membrane gave them smooth edges with precision of size (Figure 4f). The conceptual design of microfluidics or lab-on-a-chip associated with point-of-care test (POCT) applications, such as biological cell separation [1,2], nucleic acid diagnostic [3,4], bacteria detection, etc. Inertial-ordering-assisted droplet microfluidics for high-throughput single-cell RNA-sequencing. {{#each pushedProductsPlacement5}}, With DirectIndustry you can: Find the product, subcontractor or service provider you need | Find a nearby distributor or reseller| Contact the manufacturer to get a quote or a price | Examine product characteristics and technical specifications for major brands | View PDF catalogues and other online documentation. Vertical integration means your valves are the highest quality and best value. Lv J., Jiang Y., Zhang D., Zhao Y., Sun X. ; supervision, X.Z. Murray C., Miwa H., Dhar M., Park D.E., Pao E., Martinez J., Kaanumale S., Loghin E., Graf J., Raddassi K., et al. Vahid B., Boris S. Flow control using a thermally actuated microfluidic relay valve. Kim T.H., Park J., Kim C.J., Cho Y.K. High-pressure on-chip mechanical valves for thermoplastic microfluidic devices. The deionized water was then pushed out to flow through the valve which was held by a fixture, and flow rate across the valve was monitored with a flow sensor (MFS 5, Elveflow, Paris, France). [5,6] usually require high-throughput processing, autonomous actuation, and portability.
Ultrafast, sensitive and large-volume on-chip real-time PCR for the molecular diagnosis of bacterial and viral infections. The cover and the bottom (SOMOS Imagine 8000, DSM, Shanghai, China) were designed in the commercial CAD software SolidWorks (SolidWorks 2016, Dassault Systems SolidWorks Corporation, Waltham, MA, USA) and then produced on a 3D printer (Figure 4a). Magnetic-adhesive based valves for microfluidic devices used in low-resource settings. Other materials, such as thermal plastic polymer [11,12], shape memory alloy [13,14], glass [15], and more are also used in certain situations. The valve comprised of a glass cover, a silicon membrane, and a bottom layer with a spiral channel.
; resources, X.Z. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (, microfluidic, passive valve, ultra-low pressure, flow control, high flow rate. Chen C.-F., Liu J., Chang C.-C., DeVoe D.L. Fully integrated lab-on-a-disc for nucleic acid analysis of food-borne pathogens. Please refer to our Privacy Policy for details on how DirectIndustry processes your personal data. The https:// ensures that you are connecting to the We also demonstrated some smart function abilities of the valve in combination with a gas-driven flow system for obtaining high throughput and stable flow delivery under low driving pressures. Therefore, the threshold pressure of our valve is less. For many small-scale biomedical applications, precise delivery of liquid at a low-cost manner is essential for the commercialization of these miniaturized devices and systems. However, Series CKD requires a minimum back pressure of 1/2 PSI to close. As the flow resistance of the valve should be increased to compensate the pressure increment, obtaining a required flow resistance quickly enough to compensate the pressure variations with such corners could be very difficult. In addition, as it is capable of realizing self-adaptive resistance variations which completely compensate the fluidic pressure variations, a constant flow rate can, as a result, be achieved by the valve with a pre-determined threshold pressure [27,28,29]. Figure 7c shows the flow performance of the gas-driven flow system driven by a human mouth.
Temperature: 0 F - 225 FPressure: 0.5 psi - 125 psi. The cover has the inlet while the bottom has the outlet, with diameters 800 m and 600 m, respectively. *Prices are pre-tax. The prototype microvalve showed a nearly constant flow rate of 4.03 mL/min, with a variation of ~4.22% under the inlet liquid pressures varied from 6 kPa to 12 kPa. A typical membrane valve in structure would have three layers, including a control channel, a fluidic channel, and a thin elastic membrane, which can reversibly deflect to open or close the fluidic channel for flow control [9]. In order to validate the flow regulation capability of the valve, we fabricated and tested a straight through device (membraneless), and it outputted a continuously increasing flow rate in the whole test process. presented a parallel membrane valve which included two control channels, two vertical membranes, and a fluidic channel [33]. Combine these two distinctions with world class specification tools and superior customer service and your choice is clear, Specialty made in the USA. developed a silicon membrane valve for drug delivery [30]. At first, the membrane slightly deformed with the increase of the inlet pressure, which led to a high slope of the Q(P) curve. Pressure-actuated monolithic acrylic microfluidic valves and pumps. ; software, X.Z. Czilwik G., Messinger T., Strohmeier O., Wadle S., von Stetten F., Paust N., Roth G., Zengerle R., Saarinen P., Niittymaki J., et al. Zhang X., Xiang N., Tang W., Huang D., Wang X., Yi H., Ni Z. Fabrication of the microfluidic passive valve. Moon H.S., Je K., Min J.W., Park D., Han K.Y., Shin S.H., Park W.Y., Yoo C.E., Kim S.H. This paper proposes a novel microfluidic passive valve comprising of a liquid chamber, an elastic membrane, and an ellipsoidal control chamber, which actualizes a high flow rate control under an ultra-low threshold pressure. To learn more about Specialty Manufacturing Company's other product and service options visit these websites: Value added engineering-custom capabilities and 100 years of know how. will also be available for a limited time. In the experiment, an operator held the air blower and slightly squeezed it to produce the pressurized air in the tank. The .gov means its official. (a) Schematic diagram of the gas-driven flow system. and A.E.O. Zhang X., Zhu Z., Ni Z., Xiang N., Yi H. Inexpensive, rapid fabrication of polymer-film microfluidic autoregulatory valve for disposable microfluidics. Anjewierden D., Liddiard G.A., Gale B.K. Zhang C., Xing D., Li Y. Micropumps, microvalves, and micromixers within PCR microfluidic chips: Advances and trends. In our study, we found the influence of the valve structure on the flow performance to be significant, precisely considering parameters such as diameter and depth of the ellipsoid surface of the control chamber, diameter of the liquid chamber, diameter and length of the outlet, thickness and Youngs modulus of the membrane, and diameter and location of the hole in the membrane. For example, it can be applied to provide accurate sample fluids for high throughput cell sorting and concentration [40]. Kim H., Astle A.A., Najafi K., Bernal L.P., Washabaugh P.D. (b) Valve flow rate under dynamic inlet pressures. Thus, the valve could be used for high throughput sample processing in biological cell separation [36,37]. As previously mentioned, the working principle of the valve is such that flow rate across the valve is auto-regulated by the deformations of the membrane. A specialty diaphragm check valve that opens with virtually no forward pressure. The Large Check Molded Valve is an injection molded, high-purity valve constructed of 100% non-metallic materials, and featuring a PFA-wetted flow path. In comparison with the previously reported passive valves, the valve proposed in this work achieved a higher flow rate at a much lower threshold pressure, as shown in Table 1. For example, most mechanical and non-mechanical micropumps generate fluidic pressures lower than 10 kPa [38,39], which leaves the current valves with a major challenge when it comes to integrating them for such a low-pressure flow regulation. Au A.K., Lai H., Utela B.R., Folch A. Microvalves and micropumps for BioMEMS. Large-scale integration of all-glass valves on a microfluidic device. The authors gratefully acknowledge technical support from Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments in Southeast University.
A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve.
This could be attributed to the special ellipsoid surface design incorporated in the control chamber.
and transmitted securely. We understand that our customers are from diverse industries, which is why we stock a diverse selection of plastic check valve, water check valve components and similar items in many different shapes and sizes. Generally, poly(dimethylsiloxane) (PDMS) is the most commonly used membrane material due to its good optical transparency and high elasticity for large deformations [10]. Many microvalves with the functionality of on-chip actuation have been reported in previous literatures, especially the elastomeric membrane types which have been recognized as a cornerstone technology for enabling various applications in microfluidic systems [7,8]. Soft lithography. The mean flow rates under both pressure variations were 4 mL/min and 3.98 mL/min, respectively, which were quite close to those of the static pressure test. Fabrication of whole-thermoplastic normally closed microvalve, micro check valve, and micropump.
The ellipsoid surface was factored into the bottom cover design, and so it was generated by 3D printing (Figure 4g). From Equation (1), when the inlet pressure is increased beyond a threshold value, the resistance increment R automatically compensates for the pressure change P, thus a consistent flow rate Q is obtained over a range of increased pressures. The flow rate at each test pressure was measured and recorded in a minute. The liquid chamber connects to the valve inlet for liquid input. (c) Flow rate of the system operated by mouth blown air. Zhang X., Wang X., Chen K., Cheng J., Xiang N., Ni Z. ; project administration, X.Z. Fordyce P.M., Diaz-Botia C.A., DeRisi J.L., Gomez-Sjoberg R. Systematic characterization of feature dimensions and closing pressures for microfluidic valves produced via photoresist reflow. A review of microvalves. The pressure controller regulated the CDA to a target pressure and output the pressurized air into a sealed reservoir which was filled with deionized water. An alternative technology for liquid control is the passive actuation. Xia Y., Whitesides G.M. Pugliese M., Ferrara F., Bramanti A.P., Gigli G., Maiorano V. In-plane cost-effective magnetically actuated valve for microfluidic applications. 2018B04014), the Natural Science Foundation of Jiangsu Province (No. 2019K033), and the Changzhou Sci and Tech Program (No. 2019M651643), Jiangsu Planned Projects for Postdoctoral Research Funds (No. The flow regulating performance of the prototype valve under different inlet pressures are shown in Figure 6b. FOIA about navigating our updated article layout. The experimental results showed a high throughput and nearly constant flow rate achieved in the prototype under an ultra-low threshold pressure. We believe that this new microfluidic passive valve will be suitable for controlling fluid flow in portable microfluidic devices or systems of wider applications. The 3D architecture of the valve is shown in Figure 3.
Rapid and fully automated bacterial pathogen detection on a centrifugal-microfluidic LabDisk using highly sensitive nested PCR with integrated sample preparation. Cedar Grove, NJ 07009 USA Zhang W., Lin S., Wang C., Hu J., Li C., Zhuang Z., Zhou Y., Mathies R.A., Yang C.J. To quantitatively study the effect of the inlet pressure on the flow rate, we divided the flow rate curve into three phases based on the flow performances induced by the inlet pressures. For the measurement of flow rate higher than the upper limit of the flow sensor, an electronic balance (AX523ZH, OHAUS, Parsippany, NJ, USA) was used to replace the flow sensor, which measured the accumulated mass change of the liquid during one minute. The system was found to produce a stable flow rate after 0.5 s of actuation, and the mean flow rate of the system was 4.17 mL/min with a standard deviation of 0.23 mL/min, (or 5.52% of mean flow rate variation) across the time-varying pressures. The valve was made up of a control chamber of ellipsoid surface and an elastic membrane containing two micro-holes, which would deflect to change the flow resistance of the control chamber under the pressurized liquid flowing through the micro-holes, thereby maintaining a constant flow rate totally independent of the varied inlet pressures. The bottom was designed with a control chamber with an ellipsoid surface, 1500 m in diameter, and 150 m in depth. The microvalve for accurate flow control under low fluidic pressure is vital in cost-effective and miniaturized microfluidic devices. Cheng C., Nair A.R., Thakur R., Fridman G. Normally closed plunger-membrane microvalve self-actuated electrically using a shape memory alloy wire. Temperature: 0 C - 250 CPressure: 0 bar - 8.3 barDN: 12.7 mm. designed a compliant flap and a rigid stopper which formed a restricted fluid path in a planar check valve, and the valve output a high flow rate of 1.2 mL/min with a threshold pressure of 100 kPa [32]. (973) 256.3000 Fax (973) 256.4745, California Warehouse: Among the actuation mechanisms, pneumatic actuation is apparently the most commonly used technology. Flow tests were at first performed under statically varied pressures as shown in Figure 6a. As a key component of microfluidic POCT systems, a micro-scaled pumping unit for driving liquid should meet the technical functionality of the system. To investigate the flow performances of the valve, we fabricated a prototype microvalve using 3D printing and UV laser cutting technologies, and the flow rates of the prototype were measured accordingly under static and dynamic inlet pressure conditions. Zheng Y., Dai W., Wu H. A screw-actuated pneumatic valve for portable, disposable microfluidics. Learn more ; data curation, X.Z. Yang B., Lin Q. The control chamber has an ellipsoid surface, which connects to the valve outlet for liquid output. Further improvement on the flow performance of the valve could be achieved by optimizing the above parameters. The fabricated prototypes of the functional parts and the valve are shown in Figure 4d,e. Yang et al. ; formal analysis, X.Z.
In the 6 kPa to 12 kPa pressure phase, we found that the flow rate was getting regulated, as it maintained a nearly constant value regardless of pressure change.
official website and that any information you provide is encrypted
We obtained a mean flow rate of 4.03 0.17 mL/min (flow variation ~4.22%) in the above pressure range.
In addition, for the sake of cost-effectiveness and portability, the microvalve should be wholly actuated on-chip with energy efficiency. Figure 7b shows the flow rates of the gas-driven flow system driven by the air blower. As a manufacturer with over a century of experience, we have built our company to not only create the Metal and Plastic valve solutions that solve a huge range of flow control challenges, but also to manufacture and assemble them in the numbers and time-scales you need to support your production operations. Bethesda, MD 20894, Web Policies 4054 Brewster Way Because we specialize in ball check valves and similar items, we usually have something suitable for your requirements in stock, even for out-of-the-ordinary projects. ; writingreview and editing, X.Z. As the two membranes could restrict liquid in the fluidic channel with the autonomous deflection, the valve was capable of achieving flow regulation at a minimum pressure of 15 kPa. We also designed some orientation pillars and holes in each part for ease and accuracy of assembly. Oh K.W., Ahn C.H. Pourmand A., Shaegh S.A.M., Ghavifekr H.B., Najafi Aghdam E., Dokmeci M.R., Khademhosseini A., Zhang Y.S. and A.E.O. {{#pushedProductsPlacement4.length}}
In the square wave pressure experiment, we found out that flow rate abruptly increased and decreased to give peak flow and valley points when the pressures were on high and low pulsations, respectively. Automated microfluidic instrument for label-free and high-throughput cell separation. {{#each pushedProductsPlacement4}}, {{#pushedProductsPlacement5.length}} A planar compliance-based self-adaptive microfluid variable resistor. Kartalov et al. In addition, the valve structure can be further optimized to reduce the flow rate for more available microfluidic applications, such as sample mixing [41], droplet manipulation [42], drug delivery [43], etc. The system was found to output a stable liquid under the low driving pressures, which validated the applicability of the valve in portable microfluidics. (b) Simulated flow rate versus the inlet pressure in the valve. An integrated electrostatic peristaltic 18-stage gas micropump with active microvalves.
The microvalve was demonstrated to successfully regulate the steady flow delivery in the system under the low driving pressures produced by the above gas sources. Recent trends in mechanical micropumps and their applications: A review. In this work, we developed a new microfluidic passive valve which can produce a constant flow rate of liquid under an ultra-low threshold pressure.
The new PMC design is here! In the experiment, the inlet liquid pressure of the valve was increased sequentially from 1 kPa to 17 kPa by 1 kPa step. The overall force for controlling liquid in the microvalve should be minimized for convenient actuation. The flow variation defined as the relative pulsation to the mean flow rate was calculated as a ratio of the bilateral tolerance of minimum to maximum flow to the overall mean flow rate. The Riverside, CA 92501 USA -, {{product.productPrice.formattedPriceMax}}, THE LEE COMPANY miniature solenoid valves. Hence, as the valve was able to maintain a constant flow under such a low threshold pressure, we can envision its usefulness in many microfluidic applications. The explosion view shows the four parts of the valve, and the cross-section view shows the inner structure of the valve. An electrostatic microvalve for pneumatic control of microfluidic systems. When you cant find a catalog item to fill your applications requirements, we offer full custom manufacturing services to ensure you have the exact valve solution for your unique needs. Careers. The conceptualized system was composed of a pressure source, a sealed tank filled with deionized water and a microfluidic valve, shown in Figure 7a. We thought the behavior of the flow pulsation was directly influential to the response of the self-adaptive resistance variation of the valve. The air pressure produced by a strong mouth blowing was about 6.1 kPa to 8.2 kPa, which was a little higher than the minimum threshold pressure of the valve for flow stabilization. Used in applications where back flow is not permitted, or must be redirected. The pressure source employed was that of a human mouth whose blown air pressure was considered enough to drive the liquid. sharing sensitive information, make sure youre on a federal Our team had previously reported a parallel membrane valve with two horizontal membranes sandwiching a fluidic channel between them, and then all sandwiched between two control channels [34,35]. We are committed to providing every customer with a timely, consistent service that enables you to plan production, confident that the inline check valve or compressor check valve parts needed will arrive in line with the agreed schedule. Co. offers a broad range of custom brass check valve, pneumatic check valve and one way check valve options, as well as numerous other valves and related components. An experimental study on the numbering-up of microchannels for liquid mixing. Furthermore, as the design in such of an inline configuration, liquid flows directly into the control chamber from the inlet, leaving no room for pressure loss in the valve, unlike in many traditional valves made up of exterior control channels. Unger M.A., Chou H.-P., Thorsen T., Scherer A., Quake S.R. Unstable pressure Pf was produced by an air blower and by human mouth to drive liquid in the system, and stable flow rate Qs was achieved in the system. National Library of Medicine CJ20190054). Cousseau P., Hirschi R., Frehner B., Gamper S., Maillefer D. Technical Digest. Guevara-Pantoja P.E., Jimenez-Valdes R.J., Garcia-Cordero J.L., Caballero-Robledo G.A. However, these existing passive valves can be difficult to integrate into useful microfluidic due to their high threshold pressures for flow regulation. The site is secure. (d) Photograph showing the prototype functional parts of the valve. 1College of Mechanical and Electrical Engineering, Hohai University, Changzhou 213022, China; nc.ude.uhh@imeyeso.ea, 2School of Mechanical Engineering, and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing 211189, China. In the simulation, a significant nonlinear relationship was observed between the flow rate and the inlet pressure, which is attributable to the self-adaptive resistance variation characteristic of the valve as illustrated in Figure 2b. It is necessary to investigate whether the valve is indeed capable of regulating flow rate through self-adaptive resistance variation when the inlet liquid pressure varies with the actuation time. ; methodology, X.Z. To further examine the flow stability of the valve, we employed it in a portable gas-driven flow system which was operated by an air blower and human mouth blowing, respectively. (a) Simulated velocity magnitude in the valve. As described in the figure, the response time for the flow rate stabilization under the pulsating pressures was less than 0.3 s, and the standard deviation of the stable flow rate was 0.36 mL/min with the flow variation of 9.04%. Zhang X., Zhang Z. Microfluidic passive flow regulatory device with an integrated check valve for enhanced flow control. (f) Image showing the micro-holes in the membrane at position A in Figure 4d.
After that, the slope of the Q(P) curve became very small and went down to zero gradually. (e) Photograph showing a prototype of the assembled valve.
The system without the valve driven by mouth blowing showed some dramatic flow fluctuations, with a mean flow rate of 10.44 2.05 mL/min (19.64% variation). The seal layer and the membrane were designed in AutoCAD software (AutoCAD 2013, Autodesk Inc., San Rafael, CA, USA) and transferred to a UV laser machine (AWAVE 355-10W-30K, Advanced Optowave Corporation, Suffolk, NY, USA) for cutting and engraving. The black and blue dash lines represent the sinusoidal pressure and the square pressure, while the green and red solid lines represent the flow rates of the valve under the above two pressures, respectively. Flow rates of the microfluidic passive valve under varied inlet pressures. An active valve with pneumatic actuation usually employs off-chip apparatus such as an air-compressor, a pressure regulator, etc., and does the required flow regulation by the regulation of the air pressure. The inlet pressures were varied in sinusoidal wave mode and square wave mode, respectively. The standard deviation of the flow rate under sinusoidal wave pressures was 0.31 mL/min, which was equivalent to a flow variation of 7.75%. Generally, the geometry of the microvalve should be designed for a potential large-scale integration. 8600 Rockville Pike and A.E.O. Our customers frequently operate based on tight time constraints and need a resource they can rely on for the parts they need. As the commercial syringe pumps or peristaltic pumps are bulky in size while expensive in cost, it is necessary to develop a cost-effective small sized pump. (a) Concept structure of the valve. In the first phase, the flow rate was in direct proportionality to the inlet pressure, and it increased steadily as the pressure increased from 1 kPa to 6 kPa. The UV laser technology used to cut out the micro-holes in the membrane gave them smooth edges with precision of size (Figure 4f). The conceptual design of microfluidics or lab-on-a-chip associated with point-of-care test (POCT) applications, such as biological cell separation [1,2], nucleic acid diagnostic [3,4], bacteria detection, etc. Inertial-ordering-assisted droplet microfluidics for high-throughput single-cell RNA-sequencing. {{#each pushedProductsPlacement5}}, With DirectIndustry you can: Find the product, subcontractor or service provider you need | Find a nearby distributor or reseller| Contact the manufacturer to get a quote or a price | Examine product characteristics and technical specifications for major brands | View PDF catalogues and other online documentation. Vertical integration means your valves are the highest quality and best value. Lv J., Jiang Y., Zhang D., Zhao Y., Sun X. ; supervision, X.Z. Murray C., Miwa H., Dhar M., Park D.E., Pao E., Martinez J., Kaanumale S., Loghin E., Graf J., Raddassi K., et al. Vahid B., Boris S. Flow control using a thermally actuated microfluidic relay valve. Kim T.H., Park J., Kim C.J., Cho Y.K. High-pressure on-chip mechanical valves for thermoplastic microfluidic devices. The deionized water was then pushed out to flow through the valve which was held by a fixture, and flow rate across the valve was monitored with a flow sensor (MFS 5, Elveflow, Paris, France). [5,6] usually require high-throughput processing, autonomous actuation, and portability.
Ultrafast, sensitive and large-volume on-chip real-time PCR for the molecular diagnosis of bacterial and viral infections. The cover and the bottom (SOMOS Imagine 8000, DSM, Shanghai, China) were designed in the commercial CAD software SolidWorks (SolidWorks 2016, Dassault Systems SolidWorks Corporation, Waltham, MA, USA) and then produced on a 3D printer (Figure 4a). Magnetic-adhesive based valves for microfluidic devices used in low-resource settings. Other materials, such as thermal plastic polymer [11,12], shape memory alloy [13,14], glass [15], and more are also used in certain situations. The valve comprised of a glass cover, a silicon membrane, and a bottom layer with a spiral channel.
; resources, X.Z. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (, microfluidic, passive valve, ultra-low pressure, flow control, high flow rate. Chen C.-F., Liu J., Chang C.-C., DeVoe D.L. Fully integrated lab-on-a-disc for nucleic acid analysis of food-borne pathogens. Please refer to our Privacy Policy for details on how DirectIndustry processes your personal data. The https:// ensures that you are connecting to the We also demonstrated some smart function abilities of the valve in combination with a gas-driven flow system for obtaining high throughput and stable flow delivery under low driving pressures. Therefore, the threshold pressure of our valve is less. For many small-scale biomedical applications, precise delivery of liquid at a low-cost manner is essential for the commercialization of these miniaturized devices and systems. However, Series CKD requires a minimum back pressure of 1/2 PSI to close. As the flow resistance of the valve should be increased to compensate the pressure increment, obtaining a required flow resistance quickly enough to compensate the pressure variations with such corners could be very difficult. In addition, as it is capable of realizing self-adaptive resistance variations which completely compensate the fluidic pressure variations, a constant flow rate can, as a result, be achieved by the valve with a pre-determined threshold pressure [27,28,29]. Figure 7c shows the flow performance of the gas-driven flow system driven by a human mouth.
Temperature: 0 F - 225 FPressure: 0.5 psi - 125 psi. The cover has the inlet while the bottom has the outlet, with diameters 800 m and 600 m, respectively. *Prices are pre-tax. The prototype microvalve showed a nearly constant flow rate of 4.03 mL/min, with a variation of ~4.22% under the inlet liquid pressures varied from 6 kPa to 12 kPa. A typical membrane valve in structure would have three layers, including a control channel, a fluidic channel, and a thin elastic membrane, which can reversibly deflect to open or close the fluidic channel for flow control [9]. In order to validate the flow regulation capability of the valve, we fabricated and tested a straight through device (membraneless), and it outputted a continuously increasing flow rate in the whole test process. presented a parallel membrane valve which included two control channels, two vertical membranes, and a fluidic channel [33]. Combine these two distinctions with world class specification tools and superior customer service and your choice is clear, Specialty made in the USA. developed a silicon membrane valve for drug delivery [30]. At first, the membrane slightly deformed with the increase of the inlet pressure, which led to a high slope of the Q(P) curve. Pressure-actuated monolithic acrylic microfluidic valves and pumps. ; software, X.Z. Czilwik G., Messinger T., Strohmeier O., Wadle S., von Stetten F., Paust N., Roth G., Zengerle R., Saarinen P., Niittymaki J., et al. Zhang X., Xiang N., Tang W., Huang D., Wang X., Yi H., Ni Z. Fabrication of the microfluidic passive valve. Moon H.S., Je K., Min J.W., Park D., Han K.Y., Shin S.H., Park W.Y., Yoo C.E., Kim S.H. This paper proposes a novel microfluidic passive valve comprising of a liquid chamber, an elastic membrane, and an ellipsoidal control chamber, which actualizes a high flow rate control under an ultra-low threshold pressure. To learn more about Specialty Manufacturing Company's other product and service options visit these websites: Value added engineering-custom capabilities and 100 years of know how. will also be available for a limited time. In the experiment, an operator held the air blower and slightly squeezed it to produce the pressurized air in the tank. The .gov means its official. (a) Schematic diagram of the gas-driven flow system. and A.E.O. Zhang X., Zhu Z., Ni Z., Xiang N., Yi H. Inexpensive, rapid fabrication of polymer-film microfluidic autoregulatory valve for disposable microfluidics. Anjewierden D., Liddiard G.A., Gale B.K. Zhang C., Xing D., Li Y. Micropumps, microvalves, and micromixers within PCR microfluidic chips: Advances and trends. In our study, we found the influence of the valve structure on the flow performance to be significant, precisely considering parameters such as diameter and depth of the ellipsoid surface of the control chamber, diameter of the liquid chamber, diameter and length of the outlet, thickness and Youngs modulus of the membrane, and diameter and location of the hole in the membrane. For example, it can be applied to provide accurate sample fluids for high throughput cell sorting and concentration [40]. Kim H., Astle A.A., Najafi K., Bernal L.P., Washabaugh P.D. (b) Valve flow rate under dynamic inlet pressures. Thus, the valve could be used for high throughput sample processing in biological cell separation [36,37]. As previously mentioned, the working principle of the valve is such that flow rate across the valve is auto-regulated by the deformations of the membrane. A specialty diaphragm check valve that opens with virtually no forward pressure. The Large Check Molded Valve is an injection molded, high-purity valve constructed of 100% non-metallic materials, and featuring a PFA-wetted flow path. In comparison with the previously reported passive valves, the valve proposed in this work achieved a higher flow rate at a much lower threshold pressure, as shown in Table 1. For example, most mechanical and non-mechanical micropumps generate fluidic pressures lower than 10 kPa [38,39], which leaves the current valves with a major challenge when it comes to integrating them for such a low-pressure flow regulation. Au A.K., Lai H., Utela B.R., Folch A. Microvalves and micropumps for BioMEMS. Large-scale integration of all-glass valves on a microfluidic device. The authors gratefully acknowledge technical support from Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments in Southeast University.
A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve.
This could be attributed to the special ellipsoid surface design incorporated in the control chamber.
and transmitted securely. We understand that our customers are from diverse industries, which is why we stock a diverse selection of plastic check valve, water check valve components and similar items in many different shapes and sizes. Generally, poly(dimethylsiloxane) (PDMS) is the most commonly used membrane material due to its good optical transparency and high elasticity for large deformations [10]. Many microvalves with the functionality of on-chip actuation have been reported in previous literatures, especially the elastomeric membrane types which have been recognized as a cornerstone technology for enabling various applications in microfluidic systems [7,8]. Soft lithography. The mean flow rates under both pressure variations were 4 mL/min and 3.98 mL/min, respectively, which were quite close to those of the static pressure test. Fabrication of whole-thermoplastic normally closed microvalve, micro check valve, and micropump.
The ellipsoid surface was factored into the bottom cover design, and so it was generated by 3D printing (Figure 4g). From Equation (1), when the inlet pressure is increased beyond a threshold value, the resistance increment R automatically compensates for the pressure change P, thus a consistent flow rate Q is obtained over a range of increased pressures. The flow rate at each test pressure was measured and recorded in a minute. The liquid chamber connects to the valve inlet for liquid input. (c) Flow rate of the system operated by mouth blown air. Zhang X., Wang X., Chen K., Cheng J., Xiang N., Ni Z. ; project administration, X.Z. Fordyce P.M., Diaz-Botia C.A., DeRisi J.L., Gomez-Sjoberg R. Systematic characterization of feature dimensions and closing pressures for microfluidic valves produced via photoresist reflow. A review of microvalves. The pressure controller regulated the CDA to a target pressure and output the pressurized air into a sealed reservoir which was filled with deionized water. An alternative technology for liquid control is the passive actuation. Xia Y., Whitesides G.M. Pugliese M., Ferrara F., Bramanti A.P., Gigli G., Maiorano V. In-plane cost-effective magnetically actuated valve for microfluidic applications. 2018B04014), the Natural Science Foundation of Jiangsu Province (No. 2019K033), and the Changzhou Sci and Tech Program (No. 2019M651643), Jiangsu Planned Projects for Postdoctoral Research Funds (No. The flow regulating performance of the prototype valve under different inlet pressures are shown in Figure 6b. FOIA about navigating our updated article layout. The experimental results showed a high throughput and nearly constant flow rate achieved in the prototype under an ultra-low threshold pressure. We believe that this new microfluidic passive valve will be suitable for controlling fluid flow in portable microfluidic devices or systems of wider applications. The 3D architecture of the valve is shown in Figure 3.
Rapid and fully automated bacterial pathogen detection on a centrifugal-microfluidic LabDisk using highly sensitive nested PCR with integrated sample preparation. Cedar Grove, NJ 07009 USA Zhang W., Lin S., Wang C., Hu J., Li C., Zhuang Z., Zhou Y., Mathies R.A., Yang C.J. To quantitatively study the effect of the inlet pressure on the flow rate, we divided the flow rate curve into three phases based on the flow performances induced by the inlet pressures. For the measurement of flow rate higher than the upper limit of the flow sensor, an electronic balance (AX523ZH, OHAUS, Parsippany, NJ, USA) was used to replace the flow sensor, which measured the accumulated mass change of the liquid during one minute. The system was found to produce a stable flow rate after 0.5 s of actuation, and the mean flow rate of the system was 4.17 mL/min with a standard deviation of 0.23 mL/min, (or 5.52% of mean flow rate variation) across the time-varying pressures. The valve was made up of a control chamber of ellipsoid surface and an elastic membrane containing two micro-holes, which would deflect to change the flow resistance of the control chamber under the pressurized liquid flowing through the micro-holes, thereby maintaining a constant flow rate totally independent of the varied inlet pressures. The bottom was designed with a control chamber with an ellipsoid surface, 1500 m in diameter, and 150 m in depth. The microvalve for accurate flow control under low fluidic pressure is vital in cost-effective and miniaturized microfluidic devices. Cheng C., Nair A.R., Thakur R., Fridman G. Normally closed plunger-membrane microvalve self-actuated electrically using a shape memory alloy wire. Temperature: 0 C - 250 CPressure: 0 bar - 8.3 barDN: 12.7 mm. designed a compliant flap and a rigid stopper which formed a restricted fluid path in a planar check valve, and the valve output a high flow rate of 1.2 mL/min with a threshold pressure of 100 kPa [32]. (973) 256.3000 Fax (973) 256.4745, California Warehouse: Among the actuation mechanisms, pneumatic actuation is apparently the most commonly used technology. Flow tests were at first performed under statically varied pressures as shown in Figure 6a. As a key component of microfluidic POCT systems, a micro-scaled pumping unit for driving liquid should meet the technical functionality of the system. To investigate the flow performances of the valve, we fabricated a prototype microvalve using 3D printing and UV laser cutting technologies, and the flow rates of the prototype were measured accordingly under static and dynamic inlet pressure conditions. Zheng Y., Dai W., Wu H. A screw-actuated pneumatic valve for portable, disposable microfluidics. Learn more ; data curation, X.Z. Yang B., Lin Q. The control chamber has an ellipsoid surface, which connects to the valve outlet for liquid output. Further improvement on the flow performance of the valve could be achieved by optimizing the above parameters. The fabricated prototypes of the functional parts and the valve are shown in Figure 4d,e. Yang et al. ; formal analysis, X.Z.
In the 6 kPa to 12 kPa pressure phase, we found that the flow rate was getting regulated, as it maintained a nearly constant value regardless of pressure change.