1-17-2011;101(1):117-125. View abstract. A., Varadarajan, P. V., Nachane, R. P., and Balasubramanya, R. H. Functional finishing of cotton fabrics using silver nanoparticles. Available online: http://www.fda.gov/bbs/topics/ANSWERS/ANS0971.html. JAMA 1995;274:1196-7. Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos. 6-9-2010;2(6):942-952. Wu, Q., Cao, H., Luan, Q., Zhang, J., Wang, Z., Warner, J. H., and Watt, A.
Barnea, Y., Weiss, J., and Gur, E. A review of the applications of the hydrofiber dressing with silver (Aquacel Ag) in wound care. Lackner, P., Beer, R., Broessner, G., Helbok, R., Galiano, K., Pleifer, C., Pfausler, B., Brenneis, C., Huck, C., Engelhardt, K., Obwegeser, A. 2008;61(4):869-876. 7-15-2010;44(14):5649-5654. Chinese Journal of New Drugs 2010;19:605-611. View abstract. View abstract. Online retailers market colloidal silver as a cure-all for cancer and other health problems, but theres no scientific evidence to back up the claims. Colloidal silver is a controversial alternative medicine. Wu, M. H. and Wu, H. Y. View abstract. 2007;37(3):237-250.
View abstract. Skin Pharmacol Physiol 2006;19(3):140-146. DVORAK, V. [Is Crede's method still necessary?]. Water Res 2010;44(14):4105-4114. AshaRani, P. V., Low Kah, Mun G., Hande, M. P., and Valiyaveettil, S. Cytotoxicity and genotoxicity of silver nanoparticles in human cells.
Ziegler, K., Gorl, R., Effing, J., Ellermann, J., Mappes, M., Otten, S., Kapp, H., Zoellner, P., Spaeth, D., and Smola, H. Reduced cellular toxicity of a new silver-containing antimicrobial dressing and clinical performance in non-healing wounds. 2007;2(1):129-136. A. Fractionating nanosilver: importance for determining toxicity to aquatic test organisms. Diabet.Med 2007;24(3):280-288. Taherinejad F and Hamberg K. Antimicrobial effect of a silver-containing foam dressing on a broad range of common wound pathogens. View abstract. 11-1-2010;44(21):8337-8342. Facile method of preparing silver-embedded polymer beads and their antibacterial effect. Biomacromolecules. 4-30-2010;21(17):175104. Am J Hosp.Pharm 1977;34(3):287-289. Mornex, R., Zech, P., Pellet, M., and Tourniaire, J. Taking colloidal silver along with medications that might also harm the liver can increase the risk of liver damage. J Nanobiotechnology.
Percival, S. L., Bowler, P. G., and Russell, D. Bacterial resistance to silver in wound care. Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition. Colloids Surf.B Biointerfaces. Khalsa KPS.
Chaloner, D. A comparative study of two silver containing dressings, Acticoat 7 and Avance in the treatment of chronic venous ulcers. Burns 2001;27(6):621-627. J Colloid Interface Sci 11-15-2009;339(2):521-526. Colloidal silver is a solution that contains very small pieces of silver. View abstract. Toxicol.Sci 2009;108(2):223-224. Ahn, S. J., Lee, S. J., Kook, J. K., and Lim, B. S. Experimental antimicrobial orthodontic adhesives using nanofillers and silver nanoparticles. Fumal, I., Braham, C., Paquet, P., Pierard-Franchimont, C., and Pierard, G. E. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study. Castillo, P. M., Herrera, J. L., Fernandez-Montesinos, R., Caro, C., Zaderenko, A. P., Mejias, J. View abstract. View abstract. View abstract. Colloidal silver products marketed for medical purposes or promoted for unproven uses are now considered "misbranded" under the law without appropriate FDA approval as a new drug. Surg.Forum 1966;17:76-78. Jorgensen, B., Bech-Thomsen, N., Grenov, B., and Gottrup, F. Effect of a new silver dressing on chronic venous leg ulcers with signs of critical colonisation. Rattanaruengsrikul, V., Pimpha, N., and Supaphol, P. Development of gelatin hydrogel pads as antibacterial wound dressings. Sung, J. H., Ji, J. H., Song, K. S., Lee, J. H., Choi, K. H., Lee, S. H., and Yu, I. J. Int J Nanomedicine. 10-28-2005;(40):5059-5061.
2007;87(2):186-187. View abstract.
A. and Caldwell, D. R. Corneal argyrosis: histologic, ultrastructural and microanalytic study. In fact, the FDA deemed that all over-the-counter products that contain colloidal silver ingredients or silver salts are not generally recognized as safe or effective (1, 2). Silver nanoparticles as a new generation of antimicrobials.
Jaiswal, S., Duffy, B., Jaiswal, A. K., Stobie, N., and McHale, P. Enhancement of the antibacterial properties of silver nanoparticles using beta-cyclodextrin as a capping agent. Ther Clin Risk Manag. View abstract. View abstract. van, Hasselt P., Gashe, B. J Exp.Med 3-31-1926;43(4):533-553. Learn more about fenugreek's benefits, safety and side effects here. ACS Nano. A comparison of topical Phenytoin with Silverex in the treatment of superficial dermal burn wounds. View abstract.
View abstract. Toxicol.Sci 2009;108(2):452-461. Effects of an activated charcoal silver dressing on chronic wounds with no clinical signs of infection. Klotter J. Colloidal silver products were once available as over-the-counter drug products. View abstract. 1-31-2010;96(2):159-165. As a compound, the silver found in the environment is thought to be quite safe. Wyatt, D., McGowan, D. N., and Najarian, M. P. Comparison of a hydrocolloid dressing and silver sulfadiazine cream in the outpatient management of second-degree burns. Biomacromolecules. Deng, F., Olesen, P., Foldbjerg, R., Dang, D. A., Guo, X., and Autrup, H. Silver nanoparticles up-regulate Connexin43 expression and increase gap junctional intercellular communication in human lung adenocarcinoma cell line A549. Nowrouzi, A., Meghrazi, K., Golmohammadi, T., Golestani, A., Ahmadian, S., Shafiezadeh, M., Shajary, Z., Khaghani, S., and Amiri, A. N. Cytotoxicity of subtoxic AgNP in human hepatoma cell line (HepG2) after long-term exposure. A., Knetsch, M. L., Aldenhoff, Y. 2007;117(3):387-400. University of Washington. View abstract.
Toxicol.Appl Pharmacol 5-1-2009;236(3):310-318. Bae, E., Park, H. J., Lee, J., Kim, Y., Yoon, J., Park, K., Choi, K., and Yi, J. Bacterial cytotoxicity of the silver nanoparticle related to physicochemical metrics and agglomeration properties. Stevens, K. N., Crespo-Biel, O., van den Bosch, E. E., Dias, A. Van de Voorde, K., Nijsten, T., Schelfhout, K., Moorkens, G., and Lambert, J. View abstract. View abstract. 2010;7:20. Roh, J. Y., Sim, S. J., Yi, J., Park, K., Chung, K. H., Ryu, D. Y., and Choi, J. Ecotoxicity of silver nanoparticles on the soil nematode Caenorhabditis elegans using functional ecotoxicogenomics. J Wound Care 2003;12(9):351-354. Int Wound J 2009;6(1):32-38. Antimicrobials from egg whites and silver. 8-1-2009;43(15):6046-6051.
Nanotechnology.
(Lond) 2009;4(4):421-429. Aquat.Toxicol. Vet.Microbiol. J Biomater.Sci Polym.Ed 2009;20(14):2129-2144. Taking colloidal silver with tetracycline antibiotics might decrease the effectiveness of tetracycline antibiotics. View abstract. Biomacromolecules. 8-31-2010; View abstract. Sung, J. H., Ji, J. H., Park, J. D., Yoon, J. U., Kim, D. S., Jeon, K. S., Song, M. Y., Jeong, J., Han, B. S., Han, J. H., Chung, Y. H., Chang, H. K., Lee, J. H., Cho, M. H., Kelman, B. J., and Yu, I. J. Subchronic inhalation toxicity of silver nanoparticles. Ruparelia, J. P., Chatterjee, A. K., Duttagupta, S. P., and Mukherji, S. Strain specificity in antimicrobial activity of silver and copper nanoparticles. View abstract. Allen, H. J., Impellitteri, C. A., Macke, D. A., Heckman, J. L., Poynton, H. C., Lazorchak, J. M., Govindaswamy, S., Roose, D. L., and Nadagouda, M. N. Effects from filtration, capping agents, and presence/absence of food on the toxicity of silver nanoparticles to Daphnia magna. Russell, L. The CONTOP multinational study: preliminary data from the UK arm. 2010;5:261-267. View abstract. Here are 10 supplements that can reduce inflammation, backed by science. Environ Sci Technol.
Br J Nurs. View abstract. If you use silver frequently on an open wound, you may experience localized argyria due to a buildup of silver in the surrounding tissue though this condition is rare (18). View abstract. View abstract. Gopinath, P., Gogoi, S. K., Sanpui, P., Paul, A., Chattopadhyay, A., and Ghosh, S. S. Signaling gene cascade in silver nanoparticle induced apoptosis. Inhal.Toxicol. Phlebology 1988;204(Suppl):70-74. J Nanobiotechnology. Biomaterials 2009;30(22):3682-3690. 2007;12(4):527-534. View abstract. However, its thought that it binds to bacterial cells and damages their cell walls and DNA, resulting in cell death. Vigneshwaran, N., Kathe, A. Biochem.Biophys.Res Commun. J Biol Inorg.Chem. 2009;5(6):2279-2289. Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro. Shi, Q., Wang, X., Yu, W., and Huang, R. [Influence of the concentration of silver nanoparticles on the proliferation behavior of human umbilical vein endothelial cell and human umbilical artery smooth muscle cells]. 2010;5:337-342. Hinyokika Kiyo 1997;43(1):19-23. C.R.Seances Soc Biol Fil. Colloids Surf.B Biointerfaces. Better Nutrition 2008;70(1):32-33. Colloidal silver carries serious health risks if taken orally, so you should avoid it. Computerworld 2008;42(39):28. Marquez H, Boyer ML, Grove MK, and Samson MC. Cohen LE, Spurlock R, Salem A, Mercado E. Argyria in the silver state. 10-8-2009;9(10):1004-1015. View abstract. Soroff, H. S. and Sasvary, D. H. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study. Proceedings of the 17th Conference of the European Wound Management Association. View abstract. Chambers, H., Dumville, J. C., and Cullum, N. Silver treatments for leg ulcers: a systematic review. The size of the silver particles in colloidal silver varies, but some are so tiny that theyre referred to as nanoparticles. 11-12-2010; View abstract. 3-1-2010;76(1):32-37. View abstract. J Nanosci.Nanotechnol.
Kiser, M. A., Ryu, H., Jang, H., Hristovski, K., and Westerhoff, P. Biosorption of nanoparticles to heterotrophic wastewater biomass. Jeong, G. N., Jo, U. Aquat.Toxicol. Effects of repeated silver nanoparticles exposure on the histological structure and mucins of nasal respiratory mucosa in rats. Clin.Exp.Dermatol. However, its worth noting that colloidal silver products arent standardized and may have serious side effects. 2007;31(1):36-8, 16. J Clin Nurs. View abstract. Biotechnol.Bioeng. Rev Enferm 2009;32(10):7-14. ACS Appl Mater.Interfaces. 2002;44(1):24-30. Fang, C. H., Nathan, P., Robb, E. C., Alexander, J. W., and MacMillan, B. G. Prospective clinical study of Hydron, a synthetic dressing, in delivery of an antimicrobial drug to second-degree burns. A major issue is the misinterpretation of the results from test-tube and rodent studies. View abstract. View abstract. Int Wound J 2010;7(4):262-270. Trial, C., Darbas, H., Lavigne, J. P., Sotto, A., Simoneau, G., Tillet, Y., and Teot, L. Assessment of the antimicrobial effectiveness of a new silver alginate wound dressing: a RCT. View abstract. Yen, H. J., Hsu, S. H., and Tsai, C. L. Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. All rights reserved. This article explains what colloidal silver is, then details its uses, health claims, and risks.
Biomaterials 2011;32(3):693-705. ACS Nano. Jun, E. A., Lim, K. M., Kim, K., Bae, O. N., Noh, J. Y., Chung, K. H., and Chung, J. H. Silver nanoparticles enhance thrombus formation through increased platelet aggregation and procoagulant activity. This means that theyre less than 100 nanometers in size and invisible to the naked eye (6). Fichtner, J., Guresir, E., Seifert, V., and Raabe, A. Efficacy of silver-bearing external ventricular drainage catheters: a retrospective analysis. 1993; Hwang, E. T., Lee, J. H., Chae, Y. J., Kim, Y. S., Kim, B. C., Sang, B. I., and Gu, M. B. Nanotechnology.
Kim, Y. S., Kim, J. S., Cho, H. S., Rha, D. S., Kim, J. M., Park, J. D., Choi, B. S., Lim, R., Chang, H. K., Chung, Y. H., Kwon, I. H., Jeong, J., Han, B. S., and Yu, I. J. Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. View abstract. View abstract. A case of argyria after colloidal silver ingestion.
Typically, colloidal silver products are sold as homeopathic remedies. Laban, G., Nies, L. F., Turco, R. F., Bickham, J. W., and Sepulveda, M. S. The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos. Biometals 2011;24(1):135-141. View abstract. Role of sulfide and ligand strength in controlling nanosilver toxicity. Jurczak, F., Dugre, T., Johnstone, A., Offori, T., Vujovic, Z., and Hollander, D. Randomised clinical trial of Hydrofiber dressing with silver versus povidone-iodine gauze in the management of open surgical and traumatic wounds. Penicillamine is used for Wilson's disease and rheumatoid arthritis. View abstract. View abstract. Brentano, L., Margraf, H., Monafo, W. W., and Moyer, C. A. Antibacterial efficacy of a colloidal silver complex. Sci Total Environ 9-15-2009;407(19):5243-5246. J Colloid Interface Sci 10-1-2010;350(1):110-116. Colloidal silver is said to have broad antibacterial and antiseptic effects when taken orally or placed on a wound. 2008; Takeuchi, H., Hida, S., Yoshida, O., and Ueda, T. [Clinical study on efficacy of a Foley catheter coated with silver-protein in prevention of urinary tract infections]. Sawosz, E., Binek, M., Grodzik, M., Zielinska, M., Sysa, P., Szmidt, M., Niemiec, T., and Chwalibog, A. Sakai, N., Aoki, M., Miyazawa, S., Akita, M., Takezaki, S., and Kawana, S. A case of generalized argyria caused by the use of silver protein as a disinfection medicine. View abstract. Pallavicini, P., Taglietti, A., Dacarro, G., Diaz-Fernandez, Y. View abstract. J Proteome.Res 2006;5(4):916-924. View abstract. [Ophthalmia neonatorum of the newborn and its treatments in Canadian medical publications: 1872-1985]. Berberine is a compound extracted from several plants. View abstract. 2010;85(4):1115-1122. View abstract. Farkas, J., Christian, P., Gallego-Urrea, J. Case report: skin discoloration following administration of colloidal silver in cystic fibrosis. Inoue, Y., Uota, M., Torikai, T., Watari, T., Noda, I., Hotokebuchi, T., and Yada, M. Antibacterial properties of nanostructured silver titanate thin films formed on a titanium plate. Colloidal silver is LIKELY UNSAFE when taken by mouth, applied to the skin, or injected intravenously (by IV). View abstract. Rai, M., Yadav, A., and Gade, A. View abstract. View abstract. Barrett, S. Mepilex Ag: an antimicrobial, absorbent foam dressing with Safetac technology. Durucan, C. and Akkopru, B.
3-1-2010;76(1):50-56. Environ Sci Technol. Kim, Y., Suh, H. S., Cha, H. J., Kim, S. H., Jeong, K. S., and Kim, D. H. A case of generalized argyria after ingestion of colloidal silver solution. View abstract. View abstract. Bowler, P. G., Jones, S. A., Walker, M., and Parsons, D. Microbicidal properties of a silver-containing hydrofiber dressing against a variety of burn wound pathogens. 1950;6(3):173-176. NORMOBLASTOSIS PRODUCED BY INDIA INK.
Tankhiwale, R. and Bajpai, S. K. Graft copolymerization onto cellulose-based filter paper and its further development as silver nanoparticles loaded antibacterial food-packaging material. View abstract. Int J Antimicrob.Agents 2010;36(3):280-283. This might decrease the effects of penicillamine. Int J Neurosci. 2009;46(Pt 6):520-522. WOUNDS 2008;20(10):273-278. Griffitt, R. J., Hyndman, K., Denslow, N. D., and Barber, D. S. Comparison of molecular and histological changes in zebrafish gills exposed to metallic nanoparticles. Int J Antimicrob.Agents 2004;23 Suppl 1:S75-S78. Bryaskova, R., Pencheva, D., Kyulavska, M., Bozukova, D., Debuigne, A., and Detrembleur, C. Antibacterial activity of poly(vinyl alcohol)-b-poly(acrylonitrile) based micelles loaded with silver nanoparticles. WOUNDS 2003;15:371-378. Colloids Surf.B Biointerfaces. View abstract. American Biology Teacher 2009;71(4):231-234. Toxicology 1-8-2009;255(1-2):33-37. Cao, X., Tang, M., Liu, F., Nie, Y., and Zhao, C. Immobilization of silver nanoparticles onto sulfonated polyethersulfone membranes as antibacterial materials. View abstract. Zhu, C., Xue, J., and He, J. Santhoshkumar, T., Rahuman, A. (Lond) 2010;5(6):975-984. View abstract. View abstract. Kong, H. and Jang, J. Antibacterial properties of novel poly(methyl methacrylate) nanofiber containing silver nanoparticles. Chemical & Engineering News 9-27-2010;88(39):48. 2008;8(9):4734-4737. View abstract. J Nanobiotechnology. Carbohydr.Res 11-23-2009;344(17):2375-2382. Reducing the Toxicity of Antimicrobial Silver. Int Wound J 2005;2(4):348-356. [Preparation and antibacterial capacity of artificial skin loaded with nanoparticles silver using bacterial cellulose]. A new antimicrobial substance for bone cement]. View abstract. 2010;342(1-2):51-56. The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion. View abstract. View abstract. The inhibitory effects of silver nanoparticles, silver ions, and silver chloride colloids on microbial growth. Try this today: Not all alternative medicine therapies are unsafe, though the best course of action if you have a serious health condition is to consult your doctor for a treatment regimen. View abstract. View abstract. Biomed.Mater. You are most at risk of argyria if youre taking a silver-containing dietary supplement or work in a job that exposes you to large amounts of silver (14). View abstract. J Nanosci.Nanotechnol. Carbohydr.Res 11-2-2010;345(16):2374-2380. Ivins, N., Jorgensen, B., Lohmann, M., Harding, K. G., Price, P., Gottrup, F., Andersen, K. E., Bech-Thomsen, N., Scanlon, E., Roed-Petersen, J., Kirsner, R., Charles, C., Romanelli, M., Mastronicola, D., Rheinen, H., Leaper, D., Neumann, H. A. M., Munte, K., Veraart, J., Ceulen, R., Coerper, S., and Sibbald, G. Safety and efficacy in long term use of a sustained silver-releasing foam dressing: a randomised, controlled trial on venous leg ulcers. Ultimately, any colloidal silver product intended for oral use isnt safe or recommended. Last medically reviewed on January 19, 2022. Hair follicles stimulation effects of gelatin nanofibers containing silver nanoparticles. View abstract. Neurotoxicol.Teratol. Colloidal silver is a suspension of silver particles in a liquid. Kim, J. S., Kuk, E., Yu, K. N., Kim, J. H., Park, S. J., Lee, H. J., Kim, S. H., Park, Y. K., Park, Y. H., Hwang, C. Y., Kim, Y. K., Lee, Y. S., Jeong, D. H., and Cho, M. H. Antimicrobial effects of silver nanoparticles.
Nanotechnology. Caruso, D. M., Foster, K. N., Blome-Eberwein, S. A., Twomey, J. Childress, B.
Colloidal silver might decrease how much tetracycline antibiotics the body can absorb. Production of antimicrobial silver nanoparticles in water extracts of the fungus Amylomyces rouxii strain KSU-09. Kalishwaralal, K., BarathManiKanth, S., Pandian, S. R., Deepak, V., and Gurunathan, S. Silver nanoparticles impede the biofilm formation by Pseudomonas aeruginosa and Staphylococcus epidermidis. Even then, its benefits are widely debated (1, 13).
Ann Plast.Surg 2007;59(4):423-427. View abstract. View abstract. A liposome hydrogel with polyvinyl-pyrrolidone iodine in the local treatment of partial-thickness burn wounds. View abstract. Heiskanen, O., Galicich, J. H., and Matson, D. D. The effect of dilute silver nitrate and silver protein solutions on the spinal cord and nerve roots. Avicenna Journal of Medical Biotechnology 2009;1(2):111-115. 10-15-2009;55(10):24-26. Lu, L., Sun, R. W., Chen, R., Hui, C. K., Ho, C. M., Luk, J. M., Lau, G. K., and Che, C. M. Silver nanoparticles inhibit hepatitis B virus replication. Small 8-17-2009;5(16):1897-1910. View abstract. View abstract. Anaesthesia 1988;43(9):755-756. Kim, J., Kwon, S., and Ostler, E. Antimicrobial effect of silver-impregnated cellulose: potential for antimicrobial therapy. Sun, R. W., Chen, R., Chung, N. P., Ho, C. M., Lin, C. L., and Che, C. M. Silver nanoparticles fabricated in Hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells. J Colloid Interface Sci 7-1-2004;275(1):177-182. Biological effects induced by nanosilver particles: in vivo study. Vitamin D Deficiency: How Much Vitamin D Is Enough? Baker, C., Pradhan, A., Pakstis, L., Pochan, D. J., and Shah, S. I. Synthesis and antibacterial properties of silver nanoparticles. View abstract. Is that keyboard toxic? Arch Dermatol 1978;114(3):373-377. Nanotechnology. Li, W. R., Xie, X. Tidsskr.Nor Laegeforen. Z.Krebsforsch. Thomas, V., Yallapu, M. M., Sreedhar, B., and Bajpai, S. K. A versatile strategy to fabricate hydrogel-silver nanocomposites and investigation of their antimicrobial activity. Munter, K. C., Beele, H., Russell, L., Crespi, A., Grochenig, E., Basse, P., Alikadic, N., Fraulin, F., Dahl, C., and Jemma, A. P. Effect of a sustained silver-releasing dressing on ulcers with delayed healing: the CONTOP study. I. Okan, D., Woo, K., and Sibbald, R. G. So what if you are blue? Brandt, D., Park, B., Hoang, M., and Jacobe, H. T. Argyria secondary to ingestion of homemade silver solution. Seth, D., Choudhury, S. R., Pradhan, S., Gupta, S., Palit, D., Das, S., Debnath, N., and Goswami, A. Nature-inspired Novel Drug Design Paradigm Using Nanosilver: Efficacy on Multi-Drug-Resistant Clinical Isolates of Tuberculosis.
B., Ramirez, J. T., and Yacaman, M. J.
Thomas, S. and McCubbin, P. A comparison of the antimicrobial effects of four silver-containing dressings on three organisms. Consumption of colloidal silver is associated with many serious health risks, such as argyria, neurological damage, and liver and kidney harm. B. 2010;56(3):247-253. J Vasc.Surg 1992;16(2):251-257. Its unknown exactly how colloidal silver works. 3-1-2010;5(3):468-475. Adv Skin Wound.Care 2007;20(6):326-330. View abstract. Hussain, S. M. and Schlager, J. J. J Wound Care 2010;19(6):220-226. View abstract. Sharma, V. K., Yngard, R. A., and Lin, Y. Noordenbos, J., Dore, C., and Hansbrough, J. F. Safety and efficacy of TransCyte for the treatment of partial-thickness burns. People have long used red root in traditional medicine. View abstract. The bactericidal effect of silver nanoparticles. View abstract. Here is a list of 4 natural supplements that are just as effective as pharmaceutical drugs. Romo Sanz, M. I. and Juarez, Vela R. [Combined therapy for a vascular ulcer. Mar.Environ Res 2010;69 Suppl:S49-S51. View abstract. Colloidal silvers mechanisms arent fully understood. Wigginton, N. S., de, Titta A., Piccapietra, F., Dobias, J., Nesatyy, V. J., Suter, M. J., and Bernier-Latmani, R. Binding of silver nanoparticles to bacterial proteins depends on surface modifications and inhibits enzymatic activity. An experimental study on rabbits. View abstract. 2010;29(10):2154-2160. 11-1-2010;81(1):358-362. Syed, M. A., Babar, S., Bhatti, A. S., and Bokhari, H. Antibacterial effects of silver nanoparticles on the bacterial strains isolated from catheterized urinary tract infection cases. Larese, F. F., D'Agostin, F., Crosera, M., Adami, G., Renzi, N., Bovenzi, M., and Maina, G. Human skin penetration of silver nanoparticles through intact and damaged skin.
Barnea, Y., Weiss, J., and Gur, E. A review of the applications of the hydrofiber dressing with silver (Aquacel Ag) in wound care. Lackner, P., Beer, R., Broessner, G., Helbok, R., Galiano, K., Pleifer, C., Pfausler, B., Brenneis, C., Huck, C., Engelhardt, K., Obwegeser, A. 2008;61(4):869-876. 7-15-2010;44(14):5649-5654. Chinese Journal of New Drugs 2010;19:605-611. View abstract. View abstract. Online retailers market colloidal silver as a cure-all for cancer and other health problems, but theres no scientific evidence to back up the claims. Colloidal silver is a controversial alternative medicine. Wu, M. H. and Wu, H. Y. View abstract. 2007;37(3):237-250.
View abstract. Skin Pharmacol Physiol 2006;19(3):140-146. DVORAK, V. [Is Crede's method still necessary?]. Water Res 2010;44(14):4105-4114. AshaRani, P. V., Low Kah, Mun G., Hande, M. P., and Valiyaveettil, S. Cytotoxicity and genotoxicity of silver nanoparticles in human cells.
Ziegler, K., Gorl, R., Effing, J., Ellermann, J., Mappes, M., Otten, S., Kapp, H., Zoellner, P., Spaeth, D., and Smola, H. Reduced cellular toxicity of a new silver-containing antimicrobial dressing and clinical performance in non-healing wounds. 2007;2(1):129-136. A. Fractionating nanosilver: importance for determining toxicity to aquatic test organisms. Diabet.Med 2007;24(3):280-288. Taherinejad F and Hamberg K. Antimicrobial effect of a silver-containing foam dressing on a broad range of common wound pathogens. View abstract. 11-1-2010;44(21):8337-8342. Facile method of preparing silver-embedded polymer beads and their antibacterial effect. Biomacromolecules. 4-30-2010;21(17):175104. Am J Hosp.Pharm 1977;34(3):287-289. Mornex, R., Zech, P., Pellet, M., and Tourniaire, J. Taking colloidal silver along with medications that might also harm the liver can increase the risk of liver damage. J Nanobiotechnology.
Percival, S. L., Bowler, P. G., and Russell, D. Bacterial resistance to silver in wound care. Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition. Colloids Surf.B Biointerfaces. Khalsa KPS. Chaloner, D. A comparative study of two silver containing dressings, Acticoat 7 and Avance in the treatment of chronic venous ulcers. Burns 2001;27(6):621-627. J Colloid Interface Sci 11-15-2009;339(2):521-526. Colloidal silver is a solution that contains very small pieces of silver. View abstract. Toxicol.Sci 2009;108(2):223-224. Ahn, S. J., Lee, S. J., Kook, J. K., and Lim, B. S. Experimental antimicrobial orthodontic adhesives using nanofillers and silver nanoparticles. Fumal, I., Braham, C., Paquet, P., Pierard-Franchimont, C., and Pierard, G. E. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study. Castillo, P. M., Herrera, J. L., Fernandez-Montesinos, R., Caro, C., Zaderenko, A. P., Mejias, J. View abstract. View abstract. View abstract. Colloidal silver products marketed for medical purposes or promoted for unproven uses are now considered "misbranded" under the law without appropriate FDA approval as a new drug. Surg.Forum 1966;17:76-78. Jorgensen, B., Bech-Thomsen, N., Grenov, B., and Gottrup, F. Effect of a new silver dressing on chronic venous leg ulcers with signs of critical colonisation. Rattanaruengsrikul, V., Pimpha, N., and Supaphol, P. Development of gelatin hydrogel pads as antibacterial wound dressings. Sung, J. H., Ji, J. H., Song, K. S., Lee, J. H., Choi, K. H., Lee, S. H., and Yu, I. J. Int J Nanomedicine. 10-28-2005;(40):5059-5061.
2007;87(2):186-187. View abstract.
A. and Caldwell, D. R. Corneal argyrosis: histologic, ultrastructural and microanalytic study. In fact, the FDA deemed that all over-the-counter products that contain colloidal silver ingredients or silver salts are not generally recognized as safe or effective (1, 2). Silver nanoparticles as a new generation of antimicrobials.
Jaiswal, S., Duffy, B., Jaiswal, A. K., Stobie, N., and McHale, P. Enhancement of the antibacterial properties of silver nanoparticles using beta-cyclodextrin as a capping agent. Ther Clin Risk Manag. View abstract. View abstract. van, Hasselt P., Gashe, B. J Exp.Med 3-31-1926;43(4):533-553. Learn more about fenugreek's benefits, safety and side effects here. ACS Nano. A comparison of topical Phenytoin with Silverex in the treatment of superficial dermal burn wounds. View abstract.
View abstract. Toxicol.Sci 2009;108(2):452-461. Effects of an activated charcoal silver dressing on chronic wounds with no clinical signs of infection. Klotter J. Colloidal silver products were once available as over-the-counter drug products. View abstract. 1-31-2010;96(2):159-165. As a compound, the silver found in the environment is thought to be quite safe. Wyatt, D., McGowan, D. N., and Najarian, M. P. Comparison of a hydrocolloid dressing and silver sulfadiazine cream in the outpatient management of second-degree burns. Biomacromolecules. Deng, F., Olesen, P., Foldbjerg, R., Dang, D. A., Guo, X., and Autrup, H. Silver nanoparticles up-regulate Connexin43 expression and increase gap junctional intercellular communication in human lung adenocarcinoma cell line A549. Nowrouzi, A., Meghrazi, K., Golmohammadi, T., Golestani, A., Ahmadian, S., Shafiezadeh, M., Shajary, Z., Khaghani, S., and Amiri, A. N. Cytotoxicity of subtoxic AgNP in human hepatoma cell line (HepG2) after long-term exposure. A., Knetsch, M. L., Aldenhoff, Y. 2007;117(3):387-400. University of Washington. View abstract.
Toxicol.Appl Pharmacol 5-1-2009;236(3):310-318. Bae, E., Park, H. J., Lee, J., Kim, Y., Yoon, J., Park, K., Choi, K., and Yi, J. Bacterial cytotoxicity of the silver nanoparticle related to physicochemical metrics and agglomeration properties. Stevens, K. N., Crespo-Biel, O., van den Bosch, E. E., Dias, A. Van de Voorde, K., Nijsten, T., Schelfhout, K., Moorkens, G., and Lambert, J. View abstract. View abstract. 2010;7:20. Roh, J. Y., Sim, S. J., Yi, J., Park, K., Chung, K. H., Ryu, D. Y., and Choi, J. Ecotoxicity of silver nanoparticles on the soil nematode Caenorhabditis elegans using functional ecotoxicogenomics. J Wound Care 2003;12(9):351-354. Int Wound J 2009;6(1):32-38. Antimicrobials from egg whites and silver. 8-1-2009;43(15):6046-6051.
Nanotechnology.
(Lond) 2009;4(4):421-429. Aquat.Toxicol. Vet.Microbiol. J Biomater.Sci Polym.Ed 2009;20(14):2129-2144. Taking colloidal silver with tetracycline antibiotics might decrease the effectiveness of tetracycline antibiotics. View abstract. Biomacromolecules. 8-31-2010; View abstract. Sung, J. H., Ji, J. H., Park, J. D., Yoon, J. U., Kim, D. S., Jeon, K. S., Song, M. Y., Jeong, J., Han, B. S., Han, J. H., Chung, Y. H., Chang, H. K., Lee, J. H., Cho, M. H., Kelman, B. J., and Yu, I. J. Subchronic inhalation toxicity of silver nanoparticles. Ruparelia, J. P., Chatterjee, A. K., Duttagupta, S. P., and Mukherji, S. Strain specificity in antimicrobial activity of silver and copper nanoparticles. View abstract. Allen, H. J., Impellitteri, C. A., Macke, D. A., Heckman, J. L., Poynton, H. C., Lazorchak, J. M., Govindaswamy, S., Roose, D. L., and Nadagouda, M. N. Effects from filtration, capping agents, and presence/absence of food on the toxicity of silver nanoparticles to Daphnia magna. Russell, L. The CONTOP multinational study: preliminary data from the UK arm. 2010;5:261-267. View abstract. Here are 10 supplements that can reduce inflammation, backed by science. Environ Sci Technol.
Br J Nurs. View abstract. If you use silver frequently on an open wound, you may experience localized argyria due to a buildup of silver in the surrounding tissue though this condition is rare (18). View abstract. View abstract. Gopinath, P., Gogoi, S. K., Sanpui, P., Paul, A., Chattopadhyay, A., and Ghosh, S. S. Signaling gene cascade in silver nanoparticle induced apoptosis. Inhal.Toxicol. Phlebology 1988;204(Suppl):70-74. J Nanobiotechnology. Biomaterials 2009;30(22):3682-3690. 2007;12(4):527-534. View abstract. However, its thought that it binds to bacterial cells and damages their cell walls and DNA, resulting in cell death. Vigneshwaran, N., Kathe, A. Biochem.Biophys.Res Commun. J Biol Inorg.Chem. 2009;5(6):2279-2289. Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro. Shi, Q., Wang, X., Yu, W., and Huang, R. [Influence of the concentration of silver nanoparticles on the proliferation behavior of human umbilical vein endothelial cell and human umbilical artery smooth muscle cells]. 2010;5:337-342. Hinyokika Kiyo 1997;43(1):19-23. C.R.Seances Soc Biol Fil. Colloids Surf.B Biointerfaces. Better Nutrition 2008;70(1):32-33. Colloidal silver carries serious health risks if taken orally, so you should avoid it. Computerworld 2008;42(39):28. Marquez H, Boyer ML, Grove MK, and Samson MC. Cohen LE, Spurlock R, Salem A, Mercado E. Argyria in the silver state. 10-8-2009;9(10):1004-1015. View abstract. Soroff, H. S. and Sasvary, D. H. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study. Proceedings of the 17th Conference of the European Wound Management Association. View abstract. Chambers, H., Dumville, J. C., and Cullum, N. Silver treatments for leg ulcers: a systematic review. The size of the silver particles in colloidal silver varies, but some are so tiny that theyre referred to as nanoparticles. 11-12-2010; View abstract. 3-1-2010;76(1):32-37. View abstract. J Nanosci.Nanotechnol.
Kiser, M. A., Ryu, H., Jang, H., Hristovski, K., and Westerhoff, P. Biosorption of nanoparticles to heterotrophic wastewater biomass. Jeong, G. N., Jo, U. Aquat.Toxicol. Effects of repeated silver nanoparticles exposure on the histological structure and mucins of nasal respiratory mucosa in rats. Clin.Exp.Dermatol. However, its worth noting that colloidal silver products arent standardized and may have serious side effects. 2007;31(1):36-8, 16. J Clin Nurs. View abstract. Biotechnol.Bioeng. Rev Enferm 2009;32(10):7-14. ACS Appl Mater.Interfaces. 2002;44(1):24-30. Fang, C. H., Nathan, P., Robb, E. C., Alexander, J. W., and MacMillan, B. G. Prospective clinical study of Hydron, a synthetic dressing, in delivery of an antimicrobial drug to second-degree burns. A major issue is the misinterpretation of the results from test-tube and rodent studies. View abstract. View abstract. Int Wound J 2010;7(4):262-270. Trial, C., Darbas, H., Lavigne, J. P., Sotto, A., Simoneau, G., Tillet, Y., and Teot, L. Assessment of the antimicrobial effectiveness of a new silver alginate wound dressing: a RCT. View abstract. Yen, H. J., Hsu, S. H., and Tsai, C. L. Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. All rights reserved. This article explains what colloidal silver is, then details its uses, health claims, and risks.
Biomaterials 2011;32(3):693-705. ACS Nano. Jun, E. A., Lim, K. M., Kim, K., Bae, O. N., Noh, J. Y., Chung, K. H., and Chung, J. H. Silver nanoparticles enhance thrombus formation through increased platelet aggregation and procoagulant activity. This means that theyre less than 100 nanometers in size and invisible to the naked eye (6). Fichtner, J., Guresir, E., Seifert, V., and Raabe, A. Efficacy of silver-bearing external ventricular drainage catheters: a retrospective analysis. 1993; Hwang, E. T., Lee, J. H., Chae, Y. J., Kim, Y. S., Kim, B. C., Sang, B. I., and Gu, M. B. Nanotechnology.
Kim, Y. S., Kim, J. S., Cho, H. S., Rha, D. S., Kim, J. M., Park, J. D., Choi, B. S., Lim, R., Chang, H. K., Chung, Y. H., Kwon, I. H., Jeong, J., Han, B. S., and Yu, I. J. Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. View abstract. View abstract. A case of argyria after colloidal silver ingestion.
Typically, colloidal silver products are sold as homeopathic remedies. Laban, G., Nies, L. F., Turco, R. F., Bickham, J. W., and Sepulveda, M. S. The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos. Biometals 2011;24(1):135-141. View abstract. Role of sulfide and ligand strength in controlling nanosilver toxicity. Jurczak, F., Dugre, T., Johnstone, A., Offori, T., Vujovic, Z., and Hollander, D. Randomised clinical trial of Hydrofiber dressing with silver versus povidone-iodine gauze in the management of open surgical and traumatic wounds. Penicillamine is used for Wilson's disease and rheumatoid arthritis. View abstract. View abstract. Brentano, L., Margraf, H., Monafo, W. W., and Moyer, C. A. Antibacterial efficacy of a colloidal silver complex. Sci Total Environ 9-15-2009;407(19):5243-5246. J Colloid Interface Sci 10-1-2010;350(1):110-116. Colloidal silver is said to have broad antibacterial and antiseptic effects when taken orally or placed on a wound. 2008; Takeuchi, H., Hida, S., Yoshida, O., and Ueda, T. [Clinical study on efficacy of a Foley catheter coated with silver-protein in prevention of urinary tract infections]. Sawosz, E., Binek, M., Grodzik, M., Zielinska, M., Sysa, P., Szmidt, M., Niemiec, T., and Chwalibog, A. Sakai, N., Aoki, M., Miyazawa, S., Akita, M., Takezaki, S., and Kawana, S. A case of generalized argyria caused by the use of silver protein as a disinfection medicine. View abstract. Pallavicini, P., Taglietti, A., Dacarro, G., Diaz-Fernandez, Y. View abstract. J Proteome.Res 2006;5(4):916-924. View abstract. [Ophthalmia neonatorum of the newborn and its treatments in Canadian medical publications: 1872-1985]. Berberine is a compound extracted from several plants. View abstract. 2010;85(4):1115-1122. View abstract. Farkas, J., Christian, P., Gallego-Urrea, J. Case report: skin discoloration following administration of colloidal silver in cystic fibrosis. Inoue, Y., Uota, M., Torikai, T., Watari, T., Noda, I., Hotokebuchi, T., and Yada, M. Antibacterial properties of nanostructured silver titanate thin films formed on a titanium plate. Colloidal silver is LIKELY UNSAFE when taken by mouth, applied to the skin, or injected intravenously (by IV). View abstract. Rai, M., Yadav, A., and Gade, A. View abstract. View abstract. Barrett, S. Mepilex Ag: an antimicrobial, absorbent foam dressing with Safetac technology. Durucan, C. and Akkopru, B.
3-1-2010;76(1):50-56. Environ Sci Technol. Kim, Y., Suh, H. S., Cha, H. J., Kim, S. H., Jeong, K. S., and Kim, D. H. A case of generalized argyria after ingestion of colloidal silver solution. View abstract. View abstract. Bowler, P. G., Jones, S. A., Walker, M., and Parsons, D. Microbicidal properties of a silver-containing hydrofiber dressing against a variety of burn wound pathogens. 1950;6(3):173-176. NORMOBLASTOSIS PRODUCED BY INDIA INK.
Tankhiwale, R. and Bajpai, S. K. Graft copolymerization onto cellulose-based filter paper and its further development as silver nanoparticles loaded antibacterial food-packaging material. View abstract. Int J Antimicrob.Agents 2010;36(3):280-283. This might decrease the effects of penicillamine. Int J Neurosci. 2009;46(Pt 6):520-522. WOUNDS 2008;20(10):273-278. Griffitt, R. J., Hyndman, K., Denslow, N. D., and Barber, D. S. Comparison of molecular and histological changes in zebrafish gills exposed to metallic nanoparticles. Int J Antimicrob.Agents 2004;23 Suppl 1:S75-S78. Bryaskova, R., Pencheva, D., Kyulavska, M., Bozukova, D., Debuigne, A., and Detrembleur, C. Antibacterial activity of poly(vinyl alcohol)-b-poly(acrylonitrile) based micelles loaded with silver nanoparticles. WOUNDS 2003;15:371-378. Colloids Surf.B Biointerfaces. View abstract. American Biology Teacher 2009;71(4):231-234. Toxicology 1-8-2009;255(1-2):33-37. Cao, X., Tang, M., Liu, F., Nie, Y., and Zhao, C. Immobilization of silver nanoparticles onto sulfonated polyethersulfone membranes as antibacterial materials. View abstract. Zhu, C., Xue, J., and He, J. Santhoshkumar, T., Rahuman, A. (Lond) 2010;5(6):975-984. View abstract. View abstract. Kong, H. and Jang, J. Antibacterial properties of novel poly(methyl methacrylate) nanofiber containing silver nanoparticles. Chemical & Engineering News 9-27-2010;88(39):48. 2008;8(9):4734-4737. View abstract. J Nanobiotechnology. Carbohydr.Res 11-23-2009;344(17):2375-2382. Reducing the Toxicity of Antimicrobial Silver. Int Wound J 2005;2(4):348-356. [Preparation and antibacterial capacity of artificial skin loaded with nanoparticles silver using bacterial cellulose]. A new antimicrobial substance for bone cement]. View abstract. 2010;342(1-2):51-56. The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion. View abstract. View abstract. The inhibitory effects of silver nanoparticles, silver ions, and silver chloride colloids on microbial growth. Try this today: Not all alternative medicine therapies are unsafe, though the best course of action if you have a serious health condition is to consult your doctor for a treatment regimen. View abstract. View abstract. Biomed.Mater. You are most at risk of argyria if youre taking a silver-containing dietary supplement or work in a job that exposes you to large amounts of silver (14). View abstract. J Nanosci.Nanotechnol. Carbohydr.Res 11-2-2010;345(16):2374-2380. Ivins, N., Jorgensen, B., Lohmann, M., Harding, K. G., Price, P., Gottrup, F., Andersen, K. E., Bech-Thomsen, N., Scanlon, E., Roed-Petersen, J., Kirsner, R., Charles, C., Romanelli, M., Mastronicola, D., Rheinen, H., Leaper, D., Neumann, H. A. M., Munte, K., Veraart, J., Ceulen, R., Coerper, S., and Sibbald, G. Safety and efficacy in long term use of a sustained silver-releasing foam dressing: a randomised, controlled trial on venous leg ulcers. Ultimately, any colloidal silver product intended for oral use isnt safe or recommended. Last medically reviewed on January 19, 2022. Hair follicles stimulation effects of gelatin nanofibers containing silver nanoparticles. View abstract. Neurotoxicol.Teratol. Colloidal silver is a suspension of silver particles in a liquid. Kim, J. S., Kuk, E., Yu, K. N., Kim, J. H., Park, S. J., Lee, H. J., Kim, S. H., Park, Y. K., Park, Y. H., Hwang, C. Y., Kim, Y. K., Lee, Y. S., Jeong, D. H., and Cho, M. H. Antimicrobial effects of silver nanoparticles.
Nanotechnology. Caruso, D. M., Foster, K. N., Blome-Eberwein, S. A., Twomey, J. Childress, B.
Colloidal silver might decrease how much tetracycline antibiotics the body can absorb. Production of antimicrobial silver nanoparticles in water extracts of the fungus Amylomyces rouxii strain KSU-09. Kalishwaralal, K., BarathManiKanth, S., Pandian, S. R., Deepak, V., and Gurunathan, S. Silver nanoparticles impede the biofilm formation by Pseudomonas aeruginosa and Staphylococcus epidermidis. Even then, its benefits are widely debated (1, 13).
Ann Plast.Surg 2007;59(4):423-427. View abstract. View abstract. A liposome hydrogel with polyvinyl-pyrrolidone iodine in the local treatment of partial-thickness burn wounds. View abstract. Heiskanen, O., Galicich, J. H., and Matson, D. D. The effect of dilute silver nitrate and silver protein solutions on the spinal cord and nerve roots. Avicenna Journal of Medical Biotechnology 2009;1(2):111-115. 10-15-2009;55(10):24-26. Lu, L., Sun, R. W., Chen, R., Hui, C. K., Ho, C. M., Luk, J. M., Lau, G. K., and Che, C. M. Silver nanoparticles inhibit hepatitis B virus replication. Small 8-17-2009;5(16):1897-1910. View abstract. View abstract. Anaesthesia 1988;43(9):755-756. Kim, J., Kwon, S., and Ostler, E. Antimicrobial effect of silver-impregnated cellulose: potential for antimicrobial therapy. Sun, R. W., Chen, R., Chung, N. P., Ho, C. M., Lin, C. L., and Che, C. M. Silver nanoparticles fabricated in Hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells. J Colloid Interface Sci 7-1-2004;275(1):177-182. Biological effects induced by nanosilver particles: in vivo study. Vitamin D Deficiency: How Much Vitamin D Is Enough? Baker, C., Pradhan, A., Pakstis, L., Pochan, D. J., and Shah, S. I. Synthesis and antibacterial properties of silver nanoparticles. View abstract. Is that keyboard toxic? Arch Dermatol 1978;114(3):373-377. Nanotechnology. Li, W. R., Xie, X. Tidsskr.Nor Laegeforen. Z.Krebsforsch. Thomas, V., Yallapu, M. M., Sreedhar, B., and Bajpai, S. K. A versatile strategy to fabricate hydrogel-silver nanocomposites and investigation of their antimicrobial activity. Munter, K. C., Beele, H., Russell, L., Crespi, A., Grochenig, E., Basse, P., Alikadic, N., Fraulin, F., Dahl, C., and Jemma, A. P. Effect of a sustained silver-releasing dressing on ulcers with delayed healing: the CONTOP study. I. Okan, D., Woo, K., and Sibbald, R. G. So what if you are blue? Brandt, D., Park, B., Hoang, M., and Jacobe, H. T. Argyria secondary to ingestion of homemade silver solution. Seth, D., Choudhury, S. R., Pradhan, S., Gupta, S., Palit, D., Das, S., Debnath, N., and Goswami, A. Nature-inspired Novel Drug Design Paradigm Using Nanosilver: Efficacy on Multi-Drug-Resistant Clinical Isolates of Tuberculosis.
B., Ramirez, J. T., and Yacaman, M. J.
Thomas, S. and McCubbin, P. A comparison of the antimicrobial effects of four silver-containing dressings on three organisms. Consumption of colloidal silver is associated with many serious health risks, such as argyria, neurological damage, and liver and kidney harm. B. 2010;56(3):247-253. J Vasc.Surg 1992;16(2):251-257. Its unknown exactly how colloidal silver works. 3-1-2010;5(3):468-475. Adv Skin Wound.Care 2007;20(6):326-330. View abstract. Hussain, S. M. and Schlager, J. J. J Wound Care 2010;19(6):220-226. View abstract. Sharma, V. K., Yngard, R. A., and Lin, Y. Noordenbos, J., Dore, C., and Hansbrough, J. F. Safety and efficacy of TransCyte for the treatment of partial-thickness burns. People have long used red root in traditional medicine. View abstract. The bactericidal effect of silver nanoparticles. View abstract. Here is a list of 4 natural supplements that are just as effective as pharmaceutical drugs. Romo Sanz, M. I. and Juarez, Vela R. [Combined therapy for a vascular ulcer. Mar.Environ Res 2010;69 Suppl:S49-S51. View abstract. Colloidal silvers mechanisms arent fully understood. Wigginton, N. S., de, Titta A., Piccapietra, F., Dobias, J., Nesatyy, V. J., Suter, M. J., and Bernier-Latmani, R. Binding of silver nanoparticles to bacterial proteins depends on surface modifications and inhibits enzymatic activity. An experimental study on rabbits. View abstract. 2010;29(10):2154-2160. 11-1-2010;81(1):358-362. Syed, M. A., Babar, S., Bhatti, A. S., and Bokhari, H. Antibacterial effects of silver nanoparticles on the bacterial strains isolated from catheterized urinary tract infection cases. Larese, F. F., D'Agostin, F., Crosera, M., Adami, G., Renzi, N., Bovenzi, M., and Maina, G. Human skin penetration of silver nanoparticles through intact and damaged skin.